Precision Medicine & Precision Oncology

Precision medicine promises to transform the way patients are treated by using information about patient’s genes-proteins signature and environment to prevent, diagnose and treat diseases. This session aims to describe the current situation, evolving landscape and perspectives about precision oncology in Tan Tock Seng Hospital (TTSH).

The various applications of precision medicine from early cancer detection to targeted treatment will be discussed, with focus on the use of liquid biopsy approaches. With the advent of the ability to analyze genomic sequence data in a timely fashion and at an ever-decreasing cost, the use of next generation sequencing (NGS) to identify targetable alterations is rapidly developing and has entered the mainstream of clinical practice. Our hematologists have been utilizing molecular tools for the diagnostic workup of patients with Myeloproliferative Neoplasms (MPNs). The molecular landscape of MPNs and their experiences in utilizing NGS for evaluation will be presented.

Precision medicine has begun moving in the prevention direction. Patient-tailored screening programs, preventive measures and proactive treatment are possible for patients of a high-risk group. This session will highlight the development of a microRNA biomarkers panel to assess an individual‘s risk for stomach cancer. In addition, the TTSH Cancer Genetics and Genomics Clinic (CGGC) was set up in December 2017 to provide counselling service for inherited cancer syndromes diagnosis, risk assessment and treatment recommendation. Our oncologist leading the CGGC will share the experience in genetic counselling and the impact of hereditary cancer testing on clinical care.

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