KKK1, EYL1, A.A.SULE1
Tan Tock Seng Hospital1
Venous thromboembolism (VTE) is the third leading vascular diagnosis after acute coronary syndrome and stroke. Risk factors identified for VTE include increasing age, immobility, malignancy, certain drug use, hereditary thrombophilia and hyperhomocysteinemia. This study aims to determine the prevalence of hyperhomocysteinemia in patients with VTE in Tan Tock Seng Hospital and its associated risk factors.
This is a retrospective cross-sectional study. Patients ≥ 21-year-old with homocysteine levels >15 µmol/L who were admitted for VTE from 1st Jan 2010 to 30th June 2020 were included. Demographics, relevant medical history, laboratory values and concurrent medications were also collected. Data was retrieved from the Healthcare Intelligence system in Tan Tock Seng Hospital.
Fifty patients who fulfilled the inclusion criteria were included. There were 26 (52%) female and the mean age was 59. Thirty-six (72%) of the patients were Chinese. The prevalence of hyperhomocysteinemia in patients with VTE was 0.97%. There were 42 (84%) and 8 (16%) patients with moderate hyperhomocysteinemia and intermediate hyperhomocysteinemia, respectively. The incidence of deep vein thrombosis (DVT), pulmonary embolism (PE) and cerebral venous thrombosis (CVT) in these patients was 56%, 48% and 12%, respectively. Fifteen patients had both DVT and PE. Relevant medical history, laboratory values and concurrent medications did not influence the incidence of VTE occurrence in these patients.
The prevalence of hyperhomocysteinemia in patients with VTE in Tan Tock Seng Hospital appears to be higher than that previously reported. Hyperhomocysteinemia may be the likely factor to cause VTE in these patients.