SHBC1580

P.M.YEO¹, N.N.A.DE SOUZA², Y.C.TAM³, R.SULTANA², C.C.OH³ 

MOH Holdings Pte Ltd (MOHH)¹, Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore², Singapore General Hospital³

Cutaneous squamous cell carcinoma (cSCC) is the most common malignancy in solid organ transplant recipients (SOTR).

Our objective was to evaluate the efficacy of definitive and adjuvant radiotherapy for cSCC in SOTR. The Cochrane Library, PubMed, and EMBASE database were searched in March 2020. Studies with SOTR who had primary cSCC, and had radiotherapy alone or in combination with other treatment with curative intent were included. Outcomes of interest were local recurrence, regional, and distant metastases.

Only 2 cohort studies were included, resulting in a total of 27 SOTR cases of cSCC in SOTR. All 17 (63.0%) patients who underwent surgery had non-Mohs micrographic surgery. 10 (37.0%) patients had definitive radiotherapy, 6 (22.2%) patients had definitive surgery, and 11 (40.7%) patients had surgery and radiotherapy. Surgical margin status before radiotherapy was generally unreported. Other limitations of our study are the small number of studies which may reflect publication bias, and the significant heterogeneity of the included studies which precluded pooling of the results in a meta-analysis.

There is a paucity of data regarding the utility of definitive and adjuvant radiotherapy for cSCC in SOTR. Future studies are needed to address this research gap.