Scientific Programme
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Abstract
Year 2021
September 2021

SHBC1542

Abstract Title
Preliminary efficacy analysis of ADL+: a novel app-based cognitive training and physical activity intervention for older adults at risk of cognitive decline
Authors

R.RAYMOND1, M.ONG1, J.CHEW1, P.CHEW1, Z.ZENG2, B.TAN2, N.ALI1, W.S.LIM1, C.MIAO2, J.J.CHIN1

Institutions

Tan Tock Seng Hospital1, Nanyang Technological University2

Background & Hypothesis

Cognitive training and physical activity interventions may protect against cognitive decline, but are resource-intensive and lack robust evidence supporting efficacy. We developed ADL+, a novel digital tool delivering personalised, app-based home and community cognitive-physical interventions. We aim to evaluate its efficacy on cognitive function and activity levels in at-risk older adults.

Methods

Using a quasi-experimental study design, we enrolled sixty-six functionally-independent, community-dwelling older adults(71.3±5.6years) with subjective memory complaints (AD8≥2,no dementia)to a 6-month intervention using ADL+ (N=33), or a control group (educational package). Outcomes included changes in cognitive scores measured using neuropsychological test battery(NTB) total and domain Z-scores(memory, executive function and processing speed) and activity levels(Frenchay Activities Index, FAI) at baseline and 6-months. Analysis of covariance(ANCOVA) was used to assess changes in mean scores from baseline between intervention and control, adjusted for baseline scores and covariate imbalances.

 

Results

All participants completed 6-month assessments. Both intervention and control groups were similar at baseline, except for higher Geriatric Depression Scale(GDS) scores in the control group (P=0.002). At 6-months, estimated mean change in NTB Z-scores favoured the intervention group for processing speed (increase of 0.27, 95%CI:0.10-0.34,P=0.039), adjusted for baseline NTB and GDS. We also observed a significant beneficial effect of intervention on activity levels (FAI increase 2.0, 95%CI:0.52-3.5,P=0.009), but not for NTB total, memory and executive function domains.

Discussion & Conclusion

Our preliminary findings suggest that ADL+ could improve cognitive processing speed and activity levels in older adults at risk of cognitive decline. Further studies are required to ascertain the longer-term efficacy and feasibility of this intervention.

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