SHBC1530

Y.-M. SHAO¹, Y.Z.SONG¹, S.C.LIM¹

Khoo Teck Puat Hospital¹

Diabetic kidney disease (DKD), a major type 2 diabetes (T2DM) complication, is the leading cause of end stage renal failure in Singapore. While the original aim of this study is to examine the familial aggregation of DKD in Singapore, we have observed a fair percentage of family members (FMs) who were unaware of their at-risk status of body composition.

The family unit eligible to be enrolled in this study must comprise one proband (PB) and at least two family members of the proband (which can be the PB’s parents, siblings, adult children, or spouse). The PB must be T2DM for 10 years or above. The FMs need not to be T2DM. The sources of the participants came from our other ongoing cohorts, DKD/renal clinics, or the community nursing post (CNP).

A total of 39 family units (that are composed of 128 participants) have enrolled into this study (46.1% Chinese, 21.9% Malay, 30.5% Indian, 1.6% Others; 62.5% female). Of the 89 FMs, there were 78 (87.6%) and 71 (79.8%) over the normal range of percent body fat (>20.0%) and of body fat mass (>15.3kg), respectively. There was 28 FMs (31.5%) under the normal range of skeletal muscle mass (<27.1 kg).

High body fat content is known to be associated with increased CVD risks, and reduced skeletal muscle mass is known to be associated with sarcopenia. By returning the BI results to the FMs, we have highlighted and educated them on how to make changes to their daily lifestyles (e.g. diet, exercise).