Scientific Programme
Abstract
Register
Abstract
Year 2021
October 2021

SHBC1497

Abstract Title
Association of night-time systolic blood pressure variability with liver enzymes in type 2 diabetes
Authors

A.MOH1, Y.M.SHAO1, N.J.NANIMAIR1, J.B.RAHIM1, S.C.LIM2 

Institutions

Khoo Teck Puat Hospital1, Admiralty Medical Centre2 

Background & Hypothesis

Office BP measurement is conventionally used as the indicator of cardiovascular risk. However, BP is a dynamic parameter that oscillates over the short and long term influenced by diverse factors. Previous work reported that night-time blood pressure (BP) variability predicts future cardiovascular events in patients with type 2 diabetes (T2D). This study explored the association between clinical parameters and night-time BP variability.

Methods

This cross-sectional study involved 76 T2D individuals who had 24-hour ambulatory BP monitoring (ABPM) measurements [age:61±10 years; 63.2% men, body mass index (BMI):28.2±4.7 kg/m²]. Measures of nocturnal (22:00−06:00 hours) systolic BP variability included standard deviation (SD) and coefficient of variation (CV). Clinical variables assessed were age, gender, BMI, HbA1c, lipids, liver enzymes, albumin:creatinine ratio, and estimated glomerular filtration rate.

Results

Among the clinical parameters tested, only liver enzymes alanine transaminase (ALT) and aspartate transaminase (AST) emerged correlated with both nocturnal CV (rho=0.320 and 0.310 respectively, P<0.05) and SD (rho=0.261 and 0.359 respectively, P<0.05). In separate linear regression models, natural-log transformed ALT (B=0.027, 95% CI:0.009−0.045, P=0.004) and AST (B=0.027, 95% CI:0.004−0.050, P=0.024) were associated with CV after adjustment for age, gender, BMI, clinic BP, and use of anti-hypertensive drugs. Similarly, both ALT and AST were independently associated with night-time SD. Notably, ALT and AST were not associated with diurnal BP variability.

Discussion & Conclusion

We observed a significant association between night-time BP variability and liver enzymes in adults with T2D. The findings potentially suggest adverse effects of increased nocturnal BP variability on liver health, and vice versa.

Top