Khoo Teck Puat Hospital1
Motoric cognitive risk (MCR) syndrome is a pre-dementia syndrome characterized by mild cognitive impairment and slow gait. Understanding the associations of MCR syndrome allows clinicians to identify those with higher risk of developing dementia and the associated adverse health outcomes. This study aims to investigate the characteristics of MCR syndrome in a tertiary hospital.
In this retrospective cohort study, subjects between 2012 and 2017 who attended a tertiary hospital memory clinic and satisfied MCR syndrome definition were recruited. MCR syndrome was defined as patients with Clinical Dementia Rating (CDR) 0.5 and Timed Up and Go Test (TUG) of less than 10 seconds. Association between MCR syndrome, white matter changes, cognitive and physical frailty were studied using univariate and multivariate analysis.
A total of 124 patients with a mean age of 73.19 (standard deviation = 7.054) were studied. A stepwise regression model revealed that patients with MCR syndrome were older, had worse FI-CGA scores (OR = 14.19, p = 0.009), lower MTA scores (OR = 0.47, p = 0.029), and had more periventricular white matter changes (OR = 2.01, p = 0.036). There was no association found between MCR syndrome and bADL (p = 0.065) and deep white matter changes (p = 0.323).
Understanding the characteristics of patients with MCR syndrome allows clinicians to undertake a more thorough assessment. Managing cardiovascular risk factors may play a role in reducing MCR syndrome incidence as those with more periventricular white matter changes are more likely to have MCR syndrome.