S.Y.C.LEE1, C.J.LIM1, Z.J.ONG1, W.Z.E.FU1, H.LI1, M.Y.LIM1, Y.J.GAN1
Tan Tock Seng Hospital1
Laryngeal cancer is one of the most common cancers of the head and neck region. Hypopharyngeal SCCs, although less common, carry a poorer overall prognosis.
The aim of our study was to analyse the survival outcomes of patients with advanced hypopharyngeal or laryngeal cancers who underwent chemoradiotherapy as their primary treatment, and the factors that affected these outcomes.
This is a 15 year retrospective audit of head and neck patients who were on follow-up with the Otorhinolaryngology department in a single tertiary institution. Patients who were diagnosed with advanced stage (Stage 3 or 4) hypopharyngeal or laryngeal cancers from 2006-2020 and underwent chemoradiotherapy as their primary treatment were included. The departmental electronic database and clinical notes were reviewed for epidemiological data, tumour stage, treatment modality and survival outcomes, including local/regional/distal failure and death.
Majority of the patients were male with a mean age of 65-66 years old. Patients with advanced hypopharyngeal cancer had a higher death rate of 63.6% compared to 48.5% in advanced laryngeal cancer. ECOG status 3 and Clinical T stage 4 were statistically significant factors for death in advanced laryngeal cancer. Completion of both chemoradiotherapy were statistically significant for distal failure, overall failure and death in hypopharyngeal cancer. 11.8% of laryngeal cancer patients and 2.3% of hypopharyngeal cancer patients underwent salvage surgery after initial treatment with chemoradiotherapy.
In conclusion, the results of this study represent the clinical outcomes of a cohort of advanced hypopharyngeal and laryngeal cancer patients following chemoradiotherapy from a tertiary general hospital in Singapore.