Scientific Programme
Year 2021
October 2021


Abstract Title
Review of ICU Sedation Practices in Khoo Teck Puat Hospital (KTPH)



Khoo Teck Puat Hospital1

Background & Hypothesis

Light sedation and daily sedation interruption (DSI) have been associated with a decrease in duration of mechanical ventilation, ICU stay and healthcare costs in critically ill patients. Knowledge on sedation practices and their influence on patient outcomes in KTPH is currently lacking. This study aims to describe sedation practices in mechanically ventilated ICU patients.


An observational case series of sedation practices in the three KTPH ICUs was carried out. Data were collected from electronic records and analysed using descriptive and inferential statistics.


34 patients were recruited into the study. 72.7%, 100% and 23.5% of patients were prescribed sedation targets and DSI was carried out in 9.1%, 16.7% and 11.8% of patients, in CCU, SICU and MICU, respectively. Amongst patients prescribed sedation targets, 50% of them were in deep sedation in the first 48 hours.

A non-significant higher sedation dose was observed in CCU, but there was no significant difference observed in patient outcomes including self-extubations, 28-day mortality, length of stay, ventilator days.

Discussion & Conclusion

Sedation targets are less commonly prescribed in MICU compared to CCU and SICU. DSI is not routinely carried out in the 3 ICUs. This descriptive study did not show an association between prescription of sedation targets, DSI and patient outcomes. This study was carried out during the COVID-19 pandemic when the ICUs were implementing drug conservation strategies hence the study data may not be a true reflection of sedation practices.