SHBC1351

S.F.ANG¹, C.S.H.TAN¹, L.W.T.CHAN¹, L.X.GOH¹, W.Y.C.KON², R.F.VASANWALA³, W.J.LOW⁴, E.C.K.YEOH¹, S.K.W.WONG⁵, S.C.LIM¹

Khoo Teck Puat Hospital¹, Tan Tock Seng Hospital², KK Women’s & Children’s Hospital³, Changi General Hospital⁴, NHG Polyclinics⁵

Young-onset T2D (YT2D) is on the rise in Singapore. While main efforts have been geared towards identifying risk factors with the aim of retarding and managing the condition, there is sparse data on the challenges of living with diabetes. We hypothesize that YT2D patients face difficulties in their daily lives from earlier-onset diabetes and aim to uncover specific areas to focus on for improving patient care.

190 patients (onset age ≤35 years old) from our Monogenic diabetes study were subjected to EQ-5D-5L survey upon study recruitment. The survey assessed the health status of the participants in 5 dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression with 5 response levels. EQ-VAS records the participant’s self-assessed overall current health on a vertical visual analogue scale from 0-100. Health states were derived from the 5-dimension data by applying Singapore valuation set.

Majority of the patients (mean±SD age: 33.3±14.1, diabetes duration: 11.0±11.5 years) reported no problem for all 5 dimensions. However, 20.5% and 16.8% reported problems of varying severity under anxiety/depression and pain/discomfort respectively. The mean VAS score is 77.4 (range 30-100) with 32% reporting a score of ≤70. Increased (per year) age at recruitment (OR=1.03, 95% CI [1.01, 1.07], p=0.012) and Malay ethnicity OR=4.03, 95% CI [1.73, 9.39], p<0.001) were both found to associate with pain/discomfort and anxiety/depression respectively.

Our observations suggest anxiety/depression and pain/discomfort as two issues of concern faced by YT2D patients. This would provide guidance for development of patient care programs and also baseline data for cost-effective analysis.