Scientific Programme
Year 2021
October 2021


Abstract Title
Preliminary results on the study on navigating the paradigm of middle-age and elderly onset diabetes



Khoo Teck Puat Hospital1

Background & Hypothesis

A high prevalence of sarcopenia has been reported among elderly patients with type 2 diabetes mellitus. Risk factors consisting of aging and diabetes contributes to the progression of functional disability. Early detection of sarcopenia delays the development of frailty in patients with diabetes. There is scant data on the comparison between middle-age and elderly onset diabetes in terms on body composition, frailty status and cognitive function. This analysis aims to provide preliminary results on the study.


We conducted a cross-sectional study on participants from community and clinics in KTPH and AdMC.  FRAIL questionnaire was administered to determine frailty. Cognitive function was assessed by Montreal Cognitive Assessment (MoCA). Body composition was measured by bio-electrical impedance analysis. Hang grip strength (HGS) was measured by hand dynamometer.


There were 28 participants in the analysis – 2 participants in the middle-age onset diabetes group and 26 patients in the non-diabetes group. Six participants (27.3%) had low appendicular skeletal muscle mass (<7.0 kg/m2 in males and < 5.7 kg/m2 in females). The proportion of pre-frail and frail participants were 92.8% and 7.1% respectively. The frail group had lower MoCA score and HGS than the pre-frail group (MoCA 27.0 ± 0.0 vs. 28.1 ± 1.6, p=0.344; HGS 20.0 ± 2.8 kg vs. 27.0 ± 9.2 kg, p=0.301).

Discussion & Conclusion

The proportions of low muscle mass and pre-frailty/frailty are non-trivial in middle-age and elderly participants. More data is needed to determine the association between cognitive score and frailty status.