E.CHOI1, MIR S.A2
National University Hospital1, National University of Singapore2
The relationship between Hidradenitis Suppurativa (HS) and metabolic syndrome is not well understood. The aim of this study was to characterise plasma lipid profiles of HS patients to better understand this association.
HS patients and age/gender/race/comorbidity matched controls without HS were recruited. Plasma lipidomic analysis was performed with targeted mass spectrometry for identification of over 600 lipid species. Pairwise analysis using performed with paired T test, and group differences (e.g between severity stages) using ordinal logistic regression (OLR). Sensitivity analyses were performed controlling for metabolic comorbidities and concurrent therapeutics. Highly significant lipids were analysed with the receiver operating curve (ROC).
60 HS patients and 73 controls were recruited (the excess 13 controls were included in group analysis). Pairwise comparison between HS and matched control showed differences in ceramide d20:1/24:1, phosphocholine 18:0/20:1, and species from the diglyceride class. Adjusted OLR models showed differences in lipid species from the triglyceride, diglyceride, ceramide, sphingomyelin, phosphocholine and phosphatidylethanolamine class. 27 selected lipid species were used for ROC analysis, showing an AUC of between 0.87 and 1 in the ability to differentiate Hurley and PGA severity.
This study shows systemic differences in circulating plasma lipids, affirming the nature of HS as a systemic disease. Due to the exploratory nature of the study, further investigation is required to establish a causal explanation for the role of identified lipid species in disease pathogenesis. Limitations include the lack of skin analysis due to the difficulty in obtaining skin biopsies.