H.P.PHUA1, W.Y.LIM1, G. GANESAN2, J YOONG3, K.B.TAN2, J.A. ABISHEGANADEN1, A.Y.H. LIM1
Tan Tock Seng Hospital1, Ministry of Health2, Center for Economic and Social Research3
Little is known about the epidemiology of bronchiectasis in Asia. This study describes the disease burden of bronchiectasis in Singapore.
A nationwide administrative dataset was used to identify hospitalizations with bronchiectasis as a diagnosis. Population statistics and medical encounter data were used to estimate the incidence, prevalence and hospitalizations associated with hospitalization-requiring bronchiectasis.
There were 420 incident hospitalized bronchiectasis patients in 2017, giving an incidence rate of 10.6/100,000. Age-standardized incidence declined on average by 2.7% per year between 2007 and 2017. Age-standardized incidence rates of hospitalization-requiring bronchiectasis in women are also starting to exceed those in men. Incidence rates increased strongly with age in both men and women. Tuberculosis was a secondary diagnosis in 37.5% of incident hospitalizations in 2007, but has declined sharply since then. Patient survival was considerably lower in both men (5-year Relative Survival Ratios (RSR) of 0.63 (95% CI, 0.59 to 0.66)) and women ((5-year RSR of 0.75 (95% CI, 0.72 to 0.78)). The point prevalence of bronchiectasis was 147.1/100,000 in 2017, and increased sharply with age, with more than 1% of people aged 75 years and older having bronchiectasis. In 2017, there were a total of 1,105 hospitalization episodes with bronchiectasis as a primary diagnosis, which accounted for 0.2% of total acute hospitalisations and 0.3% of total acute inpatient bed-days in 2017.
Bronchiectasis is common and imposes a substantial burden on health care utilization and survival rates of patients in Singapore.